Ontology highlight
ABSTRACT:
SUBMITTER: Zhang P
PROVIDER: S-EPMC3969420 | biostudies-other | 2013 Jan
REPOSITORIES: biostudies-other
Zhang Peichuan P Judy Meredith M Lee Seung-Jae SJ Kenyon Cynthia C
Cell metabolism 20130101 1
In long-lived C. elegans insulin/IGF-1 pathway mutants, the life-extending FOXO transcription factor DAF-16 is present throughout the animal, but we find that its activity in a single tissue can delay the aging of other tissues and extend the animal's life span. To better understand the topography of DAF-16 action among the tissues, we analyzed a collection of DAF-16-regulated genes. DAF-16 regulated most of these genes in a cell-autonomous fashion, often using tissue-specific GATA factors to di ...[more]