Ontology highlight
ABSTRACT:
SUBMITTER: Cimprich KA
PROVIDER: S-EPMC39722 | biostudies-other | 1996 Apr
REPOSITORIES: biostudies-other
Cimprich K A KA Shin T B TB Keith C T CT Schreiber S L SL
Proceedings of the National Academy of Sciences of the United States of America 19960401 7
A family of proteins involved in cell cycle progression, DNA recombination, and the detection of DNA damage has been recently identified. One of the members of this family, human ATM, is defective in the cells of patients with ataxia telangiectasia and is involved in detection and response of cells to damaged DNA. Other members include Mei-41 (Drosophila melanogaster), Mec1p (Saccharomyces cerevisiae), and Rad3 (Schizosaccharomyces pombe), which are required for the S and G2/M checkpoints, as we ...[more]