Unknown

Dataset Information

0

First- and second-sphere contributions to Fe(II) site activation by cosubstrate binding in non-heme Fe enzymes.

ABSTRACT: Non-heme Fe(II) enzymes exhibit a general mechanistic strategy where binding all cosubstrates opens a coordination site on the Fe(II) for O2 activation. This study shows that strong-donor ligands, steric interactions with the substrate and second-sphere H-bonding to the facial triad carboxylate allow for five-coordinate site formation in this enzyme superfamily.

SUBMITTER: Light KM 

PROVIDER: S-EPMC3976902 | biostudies-other | 2014 Jan

REPOSITORIES: biostudies-other

Json Xml
altmetric image

Publications

First- and second-sphere contributions to Fe(II) site activation by cosubstrate binding in non-heme Fe enzymes.

Light Kenneth M KM   Hangasky John A JA   Knapp Michael J MJ   Solomon Edward I EI  

Dalton transactions (Cambridge, England : 2003) 20140101 4

Non-heme Fe(II) enzymes exhibit a general mechanistic strategy where binding all cosubstrates opens a coordination site on the Fe(II) for O2 activation. This study shows that strong-donor ligands, steric interactions with the substrate and second-sphere H-bonding to the facial triad carboxylate allow for five-coordinate site formation in this enzyme superfamily. ...[more]

Similar Datasets

Unknown Spectroscopic studies of the mononuclear non-heme Fe(II) enzyme FIH: second-sphere contributions to reactivity.
| S-EPMC3712650 | biostudies-literature
Unknown First-principles study of non-heme Fe(II) halogenase SyrB2 reactivity.
| S-EPMC2760000 | biostudies-literature
Unknown Versatility of biological non-heme Fe(II) centers in oxygen activation reactions.
| S-EPMC2720164 | biostudies-literature
Unknown Substrate placement influences reactivity in non-heme Fe(II) halogenases and hydroxylases.
| S-EPMC3630895 | biostudies-literature
Unknown Structure and function of atypically coordinated enzymatic mononuclear non-heme-Fe(II) centers.
| S-EPMC4019311 | biostudies-literature
Unknown 18O kinetic isotope effects in non-heme iron enzymes: probing the nature of Fe/O2 intermediates.
| S-EPMC2788235 | biostudies-literature
Unknown Set of Fe(II)-3-Hydroxyflavonolate Enzyme-Substrate Model Complexes of Atypically Coordinated Mononuclear Non-Heme Fe(II)-Dependent Quercetin 2,4-Dioxygenase.
| S-EPMC6644611 | biostudies-literature
Unknown Second-sphere effects on H<sub>2</sub>O<sub>2</sub> activation by non-heme Fe<sup>II</sup> complexes: role of a phenol group in the [H<sub>2</sub>O<sub>2</sub>]-dependent accumulation of Fe<sup>IV</sup>O <i>vs.</i> Fe<sup>III</sup>OOH.
| S-EPMC8653992 | biostudies-literature
Unknown Spectroscopic and DFT studies of second-sphere variants of the type 1 copper site in azurin: covalent and nonlocal electrostatic contributions to reduction potentials.
| S-EPMC3506006 | biostudies-literature
Unknown Structure-guided insights into heterocyclic ring-cleavage catalysis of the non-heme Fe (II) dioxygenase NicX.
| S-EPMC7910607 | biostudies-literature