Ontology highlight
ABSTRACT:
SUBMITTER: Light KM
PROVIDER: S-EPMC3976902 | biostudies-other | 2014 Jan
REPOSITORIES: biostudies-other
Dalton transactions (Cambridge, England : 2003) 20140101 4
Non-heme Fe(II) enzymes exhibit a general mechanistic strategy where binding all cosubstrates opens a coordination site on the Fe(II) for O2 activation. This study shows that strong-donor ligands, steric interactions with the substrate and second-sphere H-bonding to the facial triad carboxylate allow for five-coordinate site formation in this enzyme superfamily. ...[more]