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The relationship between regional abdominal fat distribution and both insulin resistance and subclinical chronic inflammation in non-diabetic adults.

ABSTRACT: Obesity is associated with a high risk of insulin resistance (IR) and its metabolic complications. It is still debated that distributions of adipose tissue relate to an excess risk of IR and chronic inflammation in different race. This study was designed to examine the relation between insulin sensitivity, chronic inflammation and central fat distribution in non-diabetic volunteers in Taiwanese.There were 328 volunteers without family history of diabetes mellitus and with normal oral glucose tolerance test enrolled. Total body fat and abdominal fat were measured. Abdominal fat was categorized into intraperitoneal (IP), retroperitoneal (RP) and subcutaneous (SC) fat. The IR index was estimated by homeostatic model assessment. Five inflammatory markers: adiponectin, leptin, tumor necrosing factor-? (TNF-?), resistin and high sensitive CRP (hs-CRP) were measured.IR was related to IP fat (r?=?0.23, p?

SUBMITTER: Hsieh CJ 

PROVIDER: S-EPMC3978053 | biostudies-other | 2014

REPOSITORIES: biostudies-other

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The relationship between regional abdominal fat distribution and both insulin resistance and subclinical chronic inflammation in non-diabetic adults.

Hsieh Ching-Jung CJ   Wang Pei-Wen PW   Chen Tse-Ying TY  

Diabetology & metabolic syndrome 20140401 1

<h4>Objective</h4>Obesity is associated with a high risk of insulin resistance (IR) and its metabolic complications. It is still debated that distributions of adipose tissue relate to an excess risk of IR and chronic inflammation in different race. This study was designed to examine the relation between insulin sensitivity, chronic inflammation and central fat distribution in non-diabetic volunteers in Taiwanese.<h4>Methods</h4>There were 328 volunteers without family history of diabetes mellitu  ...[more]

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