Ontology highlight
ABSTRACT:
SUBMITTER: Prins ND
PROVIDER: S-EPMC3978826 | biostudies-other | 2013
REPOSITORIES: biostudies-other
Prins Niels D ND Scheltens Philip P
Alzheimer's research & therapy 20131111 6
In the past decade, Alzheimer's disease drug discovery has been directed at 'disease modifying drugs' that are able to counteract the progression of Alzheimer's disease by intervening in specific parts of its neuropathological process. Passive immunization with monoclonal antibodies (mAbs) may be able to clear toxic amyloid-β species either directly or through microglia or complement activation, thereby halting the amyloid cascade and preventing neurodegeneration and cognitive and functional dec ...[more]