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De novo synthesis of multisubstituted aryl amines using alkene cross metathesis.

ABSTRACT: The olefin cross-metathesis reaction allows rapid access to 1,5-dicarbonyl intermediates which, upon treatment with a primary or secondary amine, allow the synthesis of a range of multisubstituted carbocyclic aryl amines. This de novo arene synthesis yields nonclassical substitution patterns in a regioselective and predictable approach that is compatible with several functional groups.

SUBMITTER: Tatton MR 

PROVIDER: S-EPMC3979090 | biostudies-other | 2014 Apr

REPOSITORIES: biostudies-other

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De novo synthesis of multisubstituted aryl amines using alkene cross metathesis.

Tatton Matthew R MR   Simpson Iain I   Donohoe Timothy J TJ  

Organic letters 20140319 7

The olefin cross-metathesis reaction allows rapid access to 1,5-dicarbonyl intermediates which, upon treatment with a primary or secondary amine, allow the synthesis of a range of multisubstituted carbocyclic aryl amines. This de novo arene synthesis yields nonclassical substitution patterns in a regioselective and predictable approach that is compatible with several functional groups. ...[more]

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