Ontology highlight
ABSTRACT:
SUBMITTER: Yang F
PROVIDER: S-EPMC3982086 | biostudies-other | 2014 Apr
REPOSITORIES: biostudies-other
Yang Fan F Wang Ziying Z Wei Xinbing X Han Huirong H Meng Xianfang X Zhang Yan Y Shi Weichen W Li Fengli F Xin Tao T Pang Qi Q Yi Fan F
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20140115 4
Although the innate immune response to induce postischemic inflammation is considered as an essential step in the progression of cerebral ischemia injury, the role of innate immunity mediator NLRP3 in the pathogenesis of ischemic stroke is unknown. In this study, focal ischemia was induced by middle cerebral artery occlusion in NLRP3(-/-), NOX2(-/-), or wild-type (WT) mice. By magnetic resonance imaging (MRI), Evans blue permeability, and electron microscopic analyses, we found that NLRP3 defici ...[more]