Ontology highlight
ABSTRACT:
SUBMITTER: Wu H
PROVIDER: S-EPMC3985786 | biostudies-other | 2014 Mar
REPOSITORIES: biostudies-other
Journal of the American Chemical Society 20140303 10
A practical catalytic method for enantioselective addition of an allene unit to aldimines is disclosed. Transformations are promoted by an in-situ-generated B-based catalyst that is derived from a simple, robust, and readily accessible (in multigram quantities) chiral aminoalcohol. A range of aryl-, heteroaryl-, and alkyl-substituted homoallenylamides can be obtained in 66-91% yield and 84:16 to >99:1 enantiomeric ratio through reactions performed at ambient temperature and in the presence of 0. ...[more]