Intracellular activity of tedizolid phosphate and ACH-702 versus Mycobacterium tuberculosis infected macrophages.
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ABSTRACT:
SUBMITTER: Molina-Torres CA
PROVIDER: S-EPMC3986449 | biostudies-other | 2014 Apr
REPOSITORIES: biostudies-other
Publications
Intracellular activity of tedizolid phosphate and ACH-702 versus Mycobacterium tuberculosis infected macrophages.
Molina-Torres Carmen A CA Barba-Marines Alejandra A Valles-Guerra Orestes O Ocampo-Candiani Jorge J Cavazos-Rocha Norma N Pucci Michael J MJ Castro-Garza Jorge J Vera-Cabrera Lucio L
Annals of clinical microbiology and antimicrobials 20140404
<h4>Background</h4>Due to the emergency of multidrug-resistant strains of Mycobacterium tuberculosis, is necessary the evaluation of new compounds.<h4>Findings</h4>Tedizolid, a novel oxazolidinone, and ACH-702, a new isothiazoloquinolone, were tested against M. tuberculosis infected THP-1 macrophages. These two compounds significantly decreased the number of intracellular mycobacteria at 0.25X, 1X, 4X and 16X the MIC value. The drugs were tested either in nanoparticules or in free solution.<h4>C ...[more]
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2016-01-31 | GSE64335 | GEO