A homologation approach to the synthesis of difluorinated cycloalkynes.
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ABSTRACT:
SUBMITTER: Sletten EM
PROVIDER: S-EPMC3993865 | biostudies-other | 2014 Mar
REPOSITORIES: biostudies-other
Publications
A homologation approach to the synthesis of difluorinated cycloalkynes.
Sletten Ellen M EM de Almeida Gabriela G Bertozzi Carolyn R CR
Organic letters 20140303 6
Difluorinated cyclooctynes are important reagents for labeling azido-biomolecules through copper-free click chemistry. Here, a safe, scalable synthesis of a difluorinated cyclooctyne is reported, which involves a key homologation/ring-expansion reaction. Sequential ring expansions were also employed to synthesize and study a novel difluorinated cyclononyne. ...[more]
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