Ontology highlight
ABSTRACT:
SUBMITTER: Buchanan LE
PROVIDER: S-EPMC4000827 | biostudies-other | 2014 Apr
REPOSITORIES: biostudies-other
Buchanan Lauren E LE Carr Joshua K JK Fluitt Aaron M AM Hoganson Andrew J AJ Moran Sean D SD de Pablo Juan J JJ Skinner James L JL Zanni Martin T MT
Proceedings of the National Academy of Sciences of the United States of America 20140218 16
Polyglutamine (polyQ) sequences are found in a variety of proteins, and mutational expansion of the polyQ tract is associated with many neurodegenerative diseases. We study the amyloid fibril structure and aggregation kinetics of K2Q24K2W, a model polyQ sequence. Two structures have been proposed for amyloid fibrils formed by polyQ peptides. By forming fibrils composed of both (12)C and (13)C monomers, made possible by protein expression in Escherichia coli, we can restrict vibrational delocaliz ...[more]