Ontology highlight
ABSTRACT:
SUBMITTER: Rebourcet D
PROVIDER: S-EPMC4011090 | biostudies-other | 2014 May
REPOSITORIES: biostudies-other
Rebourcet Diane D O'Shaughnessy Peter J PJ Pitetti Jean-Luc JL Monteiro Ana A O'Hara Laura L Milne Laura L Tsai Yi Ting YT Cruickshanks Lyndsey L Riethmacher Dieter D Guillou Florian F Mitchell Rod T RT van't Hof Rob R Freeman Tom C TC Nef Serge S Smith Lee B LB
Development (Cambridge, England) 20140501 10
Sertoli cells (SCs) regulate testicular fate in the differentiating gonad and are the main regulators of spermatogenesis in the adult testis; however, their role during the intervening period of testis development, in particular during adult Leydig cell (ALC) differentiation and function, remains largely unknown. To examine SC function during fetal and prepubertal development we generated two transgenic mouse models that permit controlled, cell-specific ablation of SCs in pre- and postnatal life ...[more]