Ontology highlight
ABSTRACT:
SUBMITTER: Davies DR
PROVIDER: S-EPMC40169 | biostudies-other | 1996 Jan
REPOSITORIES: biostudies-other
Proceedings of the National Academy of Sciences of the United States of America 19960101 1
There are now several crystal structures of antibody Fab fragments complexed to their protein antigens. These include Fab complexes with lysozyme, two Fab complexes with influenza virus neuraminidase, and three Fab complexes with their anti-idiotype Fabs. The pattern of binding that emerges is similar to that found with other protein-protein interactions, with good shape complementarity between the interacting surfaces and reasonable juxtapositions of polar residues so as to permit hydrogen-bond ...[more]