Ontology highlight
ABSTRACT:
SUBMITTER: Jung ME
PROVIDER: S-EPMC4027791 | biostudies-other | 2014 Apr
REPOSITORIES: biostudies-other
Jung Michael E ME Chamberlain Brian T BT Ho Chi-Lee C CL Gillespie Eugene J EJ Bradley Kenneth A KA
ACS medicinal chemistry letters 20140121 4
EGA, 1, prevents the entry of multiple viruses and bacterial toxins into mammalian cells by inhibiting vesicular trafficking. The cellular target of 1 is unknown, and a structure-activity relationship study was conducted in order to develop a strategy for target identification. A compound with midnanomolar potency was identified (2), and three photoaffinity labels were synthesized (3-5). For this series, the expected photochemistry of the phenyl azide moiety is a more important factor than the I ...[more]