Ontology highlight
ABSTRACT:
SUBMITTER: Wilanowski TM
PROVIDER: S-EPMC40297 | biostudies-other | 1995 Dec
REPOSITORIES: biostudies-other
Wilanowski T M TM Gibson J B JB Symonds J E JE
Proceedings of the National Academy of Sciences of the United States of America 19951201 26
The insertion of the blood retrotransposon into the untranslated region of exon 7 of the sn-glycerol-3-phosphate dehydrogenase-encoding gene (Gpdh) in Drosophila melanogaster induces a GPDH isozyme-GPDH-4-and alters the pattern of expression of the three normal isozymes-GPDH-1 to GPDH-3. The process of transcript terminus formation inside the retrotransposon insertion reduces the level of the Gpdh transcript that contains exon 8 and increases the level of the transcript that contains exons 1-7. ...[more]