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Apolipoprotein E gene ?4?4 is associated with elevated risk of primary open angle glaucoma in Asians: a meta-analysis.

ABSTRACT: BACKGROUND: Epidemiological studies have evaluated the association between Apolipoprotein E (APOE) gene ?2/?3/?4 polymorphism and glaucoma susceptibility. However, the published data are still inconclusive. The aim of the present study is to evaluate the impact of APOE gene ?2/?3/?4 polymorphism on glaucoma risk by using meta-analysis. METHODS: A comprehensive literature search of PubMed, EMBASE, Cochrane, Elsevier Science Direct and CNKI databases was conducted to identify relevant articles, with the last report up to January 5, 2014. Pooled odds ratio (OR) and 95% confidence interval (CI) were used to assess the strength of association by using the fixed or random effect model. RESULTS: Fifteen separate studies including 2,700 cases and 2,365 controls were included in the meta-analysis. We did not detect a significant association between APOE gene ?2/?3/?4 polymorphism and glaucoma in overall population (P?>?0.0083). In Asians, we detected an association of the ?4?4 genotype with elevated risk for glaucoma (OR?=?5.22, 95% CI?=?1.85-14.68, P?=?0.002), mainly for primary open angle glaucoma (OR?=?4.98, 95% CI?=?1.75-14.20, P?=?0.003). CONCLUSIONS: The meta-analysis suggests that APOE gene ?4?4 may be associated with elevated risk for primary open angle glaucoma in Asians. However, more epidemiologic studies based on larger sample size, case-control design and stratified by ethnicity as well as types of glaucoma are suggested to further clarify the relationship between APOE gene ?2/?3/?4 polymorphism and genetic predisposition to glaucoma.

SUBMITTER: Wang Y

PROVIDER: S-EPMC4035820 | biostudies-other | 2014

REPOSITORIES: biostudies-other

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Apolipoprotein E gene ε4ε4 is associated with elevated risk of primary open angle glaucoma in Asians: a meta-analysis.

Wang Yong Y Zhou Yan-Feng YF Zhao Bing-Ying BY Gu Zheng-Yu ZY Li Shou-Ling SL

BMC medical genetics 20140519

<h4>Background</h4>Epidemiological studies have evaluated the association between Apolipoprotein E (APOE) gene ε2/ε3/ε4 polymorphism and glaucoma susceptibility. However, the published data are still inconclusive. The aim of the present study is to evaluate the impact of APOE gene ε2/ε3/ε4 polymorphism on glaucoma risk by using meta-analysis.<h4>Methods</h4>A comprehensive literature search of PubMed, EMBASE, Cochrane, Elsevier Science Direct and CNKI databases was conducted to identify relevant ...[more]

PMID: 24885013

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Project description:PurposeTo determine the association between plasma 8-hydroxy-2'-deoxyguanosine (8-OHdG) levels, a marker for oxidative DNA damage, and patients with primary open-angle glaucoma (POAG) or its clinical phenotypes. Furthermore, we also examined the utility of plasma 8-OHdG as a potential biomarker in POAG.Materials and methodsIn a retrospective case-control study, plasma samples were obtained from 50 POAG cases and 45 glaucoma-free controls matched for age, sex, and ethnicity. 8-OHdG levels were measured in duplicate using an enzyme-linked immunosorbent assay (ELISA) on an automated ELISA analyzer.ResultsThere was no significant difference in age, sex, and systemic disease distribution between POAG cases and controls. Both mean and median 8-OHdG levels were significantly elevated in POAG cases and male subjects. The area under the receiver operating characteristic (ROC) curve value for plasma 8-OHdG was 0.653 (95% confidence interval = 0.54-0.76, p = 0.010). The cutoff values based on quartile distribution and ROC curve analysis showed that elevated plasma 8-OHdG significantly increased the risk of POAG by more than 4-folds. Plasma 8-OHdG had a sensitivity of 78% and specificity of 53%. In logistic regression analysis, 8-OHdG showed a significant effect on POAG outcome (p = 0.016) independent of age, sex, smoking, and systemic diseases. However, no significant correlation was observed between 8-OHdG and specific clinical markers of glaucoma such as intraocular pressure (p = 0.699), cup/disc ratio (p = 0.213), and the number of antiglaucoma medications (p = 0.603).ConclusionThe study shows that there is a significant association between elevated plasma 8-OHdG and POAG, supporting the role of systemic oxidative stress-induced DNA damage in POAG pathogenesis. However, with a high rate of false-positivity, plasma 8-OHdG may lack the ability to serve as a potential biomarker in POAG. Further studies in a much larger cohort are needed to confirm these findings.

Dataset Information

Apolipoprotein E gene ?4?4 is associated with elevated risk of primary open angle glaucoma in Asians: a meta-analysis.

Publications

Apolipoprotein E gene ε4ε4 is associated with elevated risk of primary open angle glaucoma in Asians: a meta-analysis.

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