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Endogenous antibodies for tumor detection.

ABSTRACT: The study of cancer immunology has provided diagnostic and therapeutic instruments through serum autoantibody biomarkers and exogenous monoclonal antibodies. While some endogenous antibodies are found within or surrounding transformed tissue, the extent to which this exists has not been entirely characterized. We find that in transgenic and xenograft mouse models of cancer, endogenous gamma immunoglobulin (IgG) is present at higher concentration in malignantly transformed organs compared to non-transformed organs in the same mouse or organs of cognate wild-type mice. The enrichment of endogenous antibodies within the malignant tissue provides a potential means of identifying and tracking malignant cells in vivo as they mutate and diversify. Exploiting these antibodies for diagnostic and therapeutic purposes is possible through the use of agents that bind endogenous antibodies.

SUBMITTER: Rich BS

PROVIDER: S-EPMC4038850 | biostudies-other | 2014 May

REPOSITORIES: biostudies-other

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Endogenous antibodies for tumor detection.

Rich Barrie S BS Honeyman Joshua N JN Darcy David G DG Smith Peter T PT Williams Andrew R AR Lim Irene Isabel P II Johnson Linda K LK Gönen Mithat M Simon Joel S JS LaQuaglia Michael P MP Simon Sanford M SM

Scientific reports 20140530

The study of cancer immunology has provided diagnostic and therapeutic instruments through serum autoantibody biomarkers and exogenous monoclonal antibodies. While some endogenous antibodies are found within or surrounding transformed tissue, the extent to which this exists has not been entirely characterized. We find that in transgenic and xenograft mouse models of cancer, endogenous gamma immunoglobulin (IgG) is present at higher concentration in malignantly transformed organs compared to non- ...[more]

PMID: 24875800

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