Ontology highlight
ABSTRACT:
SUBMITTER: Cao Y
PROVIDER: S-EPMC4039114 | biostudies-other | 2014 Apr
REPOSITORIES: biostudies-other
Cao Yan Y Xu Yan Y Zhang Lei L Li Zhen Z Jiang Ying Y Tian Xiao X Seluanov Andrei A Gorbunova Vera V Mao Zhiyong Z
Oncotarget 20140401 7
Cancer therapy that specifically targets malignant cells with minimal or no toxicity to normal tissue has been a long-standing goal of cancer research. Rad51 expression is elevated in a wide range of cancers and Rad51 promoter has been used to transcriptionally target tumor cells, however, a large size of Rad51 promoter limits its application for gene therapy. To identify novel tumor-specific promoters, we examined expression levels of Rad51 paralogs, Rad51B, Rad51C, and Rad51D as well as Rad52 ...[more]