Ontology highlight
ABSTRACT:
SUBMITTER: Herz HM
PROVIDER: S-EPMC4049186 | biostudies-other | 2014 Mar
REPOSITORIES: biostudies-other
Herz Hans-Martin HM Hu Deqing D Shilatifard Ali A
Molecular cell 20140301 6
Why certain point mutations in a general transcription factor are associated with specific forms of cancer has been a major question in cancer biology. Enhancers are DNA regulatory elements that are key regulators of tissue-specific gene expression. Recent studies suggest that enhancer malfunction through point mutations in either regulatory elements or factors modulating enhancer-promoter communication could be the cause of tissue-specific cancer development. In this Perspective, we will discus ...[more]