Growth hormone is secreted by normal breast epithelium upon progesterone stimulation and increases proliferation of stem/progenitor cells.
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ABSTRACT:
SUBMITTER: Lombardi S
PROVIDER: S-EPMC4050343 | biostudies-other | 2014 Jun
REPOSITORIES: biostudies-other
Publications
Growth hormone is secreted by normal breast epithelium upon progesterone stimulation and increases proliferation of stem/progenitor cells.
Lombardi Sara S Honeth Gabriella G Ginestier Christophe C Shinomiya Ireneusz I Marlow Rebecca R Buchupalli Bharath B Gazinska Patrycja P Brown John J Catchpole Steven S Liu Suling S Barkan Ariel A Wicha Max M Purushotham Anand A Burchell Joy J Pinder Sarah S Dontu Gabriela G
Stem cell reports 20140603 6
Using in vitro and in vivo experimental systems and in situ analysis, we show that growth hormone (GH) is secreted locally by normal human mammary epithelial cells upon progesterone stimulation. GH increases proliferation of a subset of cells that express growth hormone receptor (GHR) and have functional properties of stem and early progenitor cells. In 72% of ductal carcinoma in situ lesions, an expansion of the cell population that expresses GHR was observed, suggesting that GH signaling may c ...[more]
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