Effectively identifying regulatory hotspots while capturing expression heterogeneity in gene expression studies.
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ABSTRACT:
SUBMITTER: Joo JW
PROVIDER: S-EPMC4053820 | biostudies-other | 2014 Apr
REPOSITORIES: biostudies-other
Publications
Effectively identifying regulatory hotspots while capturing expression heterogeneity in gene expression studies.
Joo Jong Wha J JW Sul Jae Hoon JH Han Buhm B Ye Chun C Eskin Eleazar E
Genome biology 20140407 4
Expression quantitative trait loci (eQTL) mapping is a tool that can systematically identify genetic variation affecting gene expression. eQTL mapping studies have shown that certain genomic locations, referred to as regulatory hotspots, may affect the expression levels of many genes. Recently, studies have shown that various confounding factors may induce spurious regulatory hotspots. Here, we introduce a novel statistical method that effectively eliminates spurious hotspots while retaining gen ...[more]
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