Ontology highlight
ABSTRACT:
SUBMITTER: Bartocci C
PROVIDER: S-EPMC4054697 | biostudies-other | 2014 May
REPOSITORIES: biostudies-other
Bartocci Cristina C Diedrich Jolene K JK Ouzounov Iliana I Li Julia J Piunti Andrea A Pasini Diego D Yates John R JR Lazzerini Denchi Eros E
Cell reports 20140509 4
When telomeres become critically short, DNA damage response factors are recruited at chromosome ends, initiating a cellular response to DNA damage. We performed proteomic isolation of chromatin fragments (PICh) in order to define changes in chromatin composition that occur upon onset of acute telomere dysfunction triggered by depletion of the telomere-associated factor TRF2. This unbiased purification of telomere-associated proteins in functional or dysfunctional conditions revealed the dynamic ...[more]