Ontology highlight
ABSTRACT:
SUBMITTER: Stevenson HP
PROVIDER: S-EPMC4060711 | biostudies-other | 2014 Jun
REPOSITORIES: biostudies-other
Stevenson Hilary P HP Makhov Alexander M AM Calero Monica M Edwards Andrea L AL Zeldin Oliver B OB Mathews Irimpan I II Lin Guowu G Barnes Christopher O CO Santamaria Hugo H Ross Ted M TM Soltis S Michael SM Khosla Chaitan C Nagarajan V V Conway James F JF Cohen Aina E AE Calero Guillermo G
Proceedings of the National Academy of Sciences of the United States of America 20140528 23
The current practice for identifying crystal hits for X-ray crystallography relies on optical microscopy techniques that are limited to detecting crystals no smaller than 5 μm. Because of these limitations, nanometer-sized protein crystals cannot be distinguished from common amorphous precipitates, and therefore go unnoticed during screening. These crystals would be ideal candidates for further optimization or for femtosecond X-ray protein nanocrystallography. The latter technique offers the pos ...[more]