Ontology highlight
ABSTRACT:
SUBMITTER: Lodhi N
PROVIDER: S-EPMC4066802 | biostudies-other | 2014 Jun
REPOSITORIES: biostudies-other
Lodhi Niraj N Kossenkov Andrew V AV Tulin Alexei V AV
Nucleic acids research 20140526 11
Epigenetics are the heritable changes in gene expression or cellular phenotype caused by mechanisms other than changes in the underlying DNA sequence. After mitosis, it is thought that bookmarking transcription factors remain at promoters, regulating which genes become active and which remain silent. Herein, we demonstrate that poly(ADP-ribose)polymerase-1 (PARP-1) is a genome-wide epigenetic memory mark in mitotic chromatin, and we further show that the presence of PARP-1 is absolutely crucial ...[more]