Ontology highlight
ABSTRACT:
SUBMITTER: Irwin SM
PROVIDER: S-EPMC4068578 | biostudies-other | 2014 Jul
REPOSITORIES: biostudies-other
Irwin Scott M SM Gruppo Veronica V Brooks Elizabeth E Gilliland Janet J Scherman Michael M Reichlen Matthew J MJ Leistikow Rachel R Kramnik Igor I Nuermberger Eric L EL Voskuil Martin I MI Lenaerts Anne J AJ
Antimicrobial agents and chemotherapy 20140505 7
New drugs and drugs with a novel mechanism of action are desperately needed to shorten the duration of tuberculosis treatment, to prevent the emergence of drug resistance, and to treat multiple-drug-resistant strains of Mycobacterium tuberculosis. Recently, there has been renewed interest in clofazimine (CFZ). In this study, we utilized the C3HeB/FeJ mouse model, possessing highly organized, hypoxic pulmonary granulomas with caseous necrosis, to evaluate CFZ monotherapy in comparison to results ...[more]