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A new biocompatible and antibacterial phosphate free glass-ceramic for medical applications.


ABSTRACT: In the attempt to find valid alternatives to classic antibiotics and in view of current limitations in the efficacy of antimicrobial-coated or loaded biomaterials, this work is focused on the development of a new glass-ceramic with antibacterial performance together with safe biocompatibility. This bactericidal glass-ceramic composed of combeite and nepheline crystals in a residual glassy matrix has been obtained using an antimicrobial soda-lime glass as a precursor. Its inhibitory effects on bacterial growth and biofilm formation were proved against five biofilm-producing reference strains. The biocompatibility tests by using mesenchymal stem cells derived from human bone indicate an excellent biocompatibility.

SUBMITTER: Cabal B 

PROVIDER: S-EPMC4069691 | biostudies-other | 2014

REPOSITORIES: biostudies-other

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