Ontology highlight
ABSTRACT:
SUBMITTER: DiCroce PA
PROVIDER: S-EPMC40751 | biostudies-other | 1995 Oct
REPOSITORIES: biostudies-other
DiCroce P A PA Krontiris T G TG
Proceedings of the National Academy of Sciences of the United States of America 19951001 22
The majority of translocations involving BCL2 are very narrowly targeted to three breakpoint clusters evenly spaced over a 100-bp region of the gene's terminal exon. We have recently shown that the immediate upstream boundary of this major breakpoint region (mbr) is a specific recognition site for single-strand DNA (ssDNA) binding proteins on the sense and antisense strands. The downstream flank of the mbr is a helicase binding site. In this report we demonstrate that the helicase and ssDNA bind ...[more]