Ontology highlight
ABSTRACT:
SUBMITTER: Su JY
PROVIDER: S-EPMC40761 | biostudies-other | 1995 Oct
REPOSITORIES: biostudies-other
Su J Y JY Rempel R E RE Erikson E E Maller J L JL
Proceedings of the National Academy of Sciences of the United States of America 19951001 22
We have isolated a gene encoding Xic-1, a 27-kDa cyclin-dependent kinase (Cdk) inhibitor from Xenopus ovary that shares significant homology with both mammalian CIP1 and Kip1/Kip2. The N- and C-terminal halves of Xic-1 are sufficient for interacting with Cdks and proliferating cell nuclear antigen, respectively. Recombinant Xic-1 inhibits Xenopus cyclin E/Cdk2, cyclin A/Cdk2 and cyclin B/Cdc2 activities, although with quite different IC50 values. Truncation of the N terminus of Xic-1 increases t ...[more]