Ontology highlight
ABSTRACT:
SUBMITTER: Brinkmann U
PROVIDER: S-EPMC40810 | biostudies-other | 1995 Oct
REPOSITORIES: biostudies-other
Brinkmann U U Brinkmann E E Gallo M M Pastan I I
Proceedings of the National Academy of Sciences of the United States of America 19951001 22
We recently isolated human cDNA fragments that render MCF-7 breast cancer cells resistant to cell death caused by Pseudomonas exotoxin, Pseudomonas exotoxin-derived immunotoxins, diphtheria toxin, and tumor necrosis factor. We report here that one of these fragments is an antisense fragment of a gene homologous to the essential yeast chromosome segregation gene CSE1. Cloning and analysis of the full-length cDNA of the human CSE1 homologue, which we name CAS for cellular apoptosis susceptibility ...[more]