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Who qualifies for deep brain stimulation for OCD? Data from a naturalistic clinical sample.


ABSTRACT: A few patients with obsessive-compulsive disorder (OCD) remain severely impaired despite exhausting best-practice treatments. For them, neurosurgery (stereotactic ablation or deep brain stimulation) might be considered. The authors investigated the proportion of treatment-seeking OCD patients, in a naturalistic clinical sample, who met contemporary neurosurgery selection criteria. Using comprehensive baseline data on diagnosis, severity, and treatment history for adult patients from the NIMH-supported Brown Longitudinal OCD Study, only 2 of 325 patients met screening criteria for neurosurgery. This finding prompts consideration of new models for clinical trials with limited samples as well as methods of refining entry criteria for such invasive treatments.

SUBMITTER: Garnaat SL 

PROVIDER: S-EPMC4093791 | biostudies-other | 2014

REPOSITORIES: biostudies-other

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Who qualifies for deep brain stimulation for OCD? Data from a naturalistic clinical sample.

Garnaat Sarah L SL   Greenberg Benjamin D BD   Sibrava Nicholas J NJ   Goodman Wayne K WK   Mancebo Maria C MC   Eisen Jane L JL   Rasmussen Steven A SA  

The Journal of neuropsychiatry and clinical neurosciences 20140101 1


A few patients with obsessive-compulsive disorder (OCD) remain severely impaired despite exhausting best-practice treatments. For them, neurosurgery (stereotactic ablation or deep brain stimulation) might be considered. The authors investigated the proportion of treatment-seeking OCD patients, in a naturalistic clinical sample, who met contemporary neurosurgery selection criteria. Using comprehensive baseline data on diagnosis, severity, and treatment history for adult patients from the NIMH-sup  ...[more]

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