Ontology highlight
ABSTRACT:
SUBMITTER: Malhotra A
PROVIDER: S-EPMC4094523 | biostudies-other | 2014
REPOSITORIES: biostudies-other
Malhotra Alka A Kobes Sayuko S Bogardus Clifton C Knowler William C WC Baier Leslie J LJ Hanson Robert L RL
PloS one 20140711 7
<h4>Background</h4>Genotype imputation is commonly used in genetic association studies to test untyped variants using information on linkage disequilibrium (LD) with typed markers. Imputing genotypes requires a suitable reference population in which the LD pattern is known, most often one selected from HapMap. However, some populations, such as American Indians, are not represented in HapMap. In the present study, we assessed accuracy of imputation using HapMap reference populations in a genome- ...[more]