Dataset Information

Assessing the Role of 98 Established Loci for BMI in American Indians.

ABSTRACT:

Objective

Meta-analyses of genome-wide association studies in Europeans have identified > 98 loci for BMI. Transferability of these established associations in Pima Indians was analyzed.

Methods

Among 98 lead single nucleotide polymorphisms (SNPs), 82 had minor allele frequency ? 0.01 in Pima Indians and were analyzed for association with the maximum BMI in adulthood (n = 3,491) and BMI z score in childhood (n = 1,958). Common tag SNPs across 98 loci were also analyzed for additional signals.

Results

Among the lead SNPs, 13 (TMEM18, TCF7L2, MRPS33P4, PRKD1, ZFP64, FTO, TAL1, CALCR, GNPDA2, CREB1, LMX1B, ADCY9, NLRC3) were associated with BMI (P ?? 0.05) in Pima adults. A multi-allelic genetic risk score (GRS), which summed the risk alleles for 82 lead SNPs, showed a significant trend for a positive relationship between GRS and BMI in adulthood (beta = 0.48% per risk allele; P = 1.6 × 10^-9 ) and BMI z score in childhood (beta = 0.024 SD; P = 1.7 × 10^-7 ). GRS was significantly associated with BMI across all age groups ? 5 years, except for those ? 50 years. The strongest association was seen in adolescence (age 14-16 years; P = 1.84 × 10^-9 ).

Conclusions

In aggregate, European-derived lead SNPs had a notable effect on BMI in Pima Indians. Polygenic obesity in this population manifests strongly in childhood and adolescence and persists throughout much of adult life.

SUBMITTER: Muller YL

PROVIDER: S-EPMC6478540 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

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Publications

Assessing the Role of 98 Established Loci for BMI in American Indians.

Muller Yunhua L YL Hanson Robert L RL Piaggi Paolo P Chen Peng P Wiessner Gregory G Okani Chidinma C Skelton Graham G Kobes Sayuko S Hsueh Wen-Chi WC Knowler William C WC Bogardus Clifton C Baier Leslie J LJ

Obesity (Silver Spring, Md.) 20190318 5

<h4>Objective</h4>Meta-analyses of genome-wide association studies in Europeans have identified > 98 loci for BMI. Transferability of these established associations in Pima Indians was analyzed.<h4>Methods</h4>Among 98 lead single nucleotide polymorphisms (SNPs), 82 had minor allele frequency ≥ 0.01 in Pima Indians and were analyzed for association with the maximum BMI in adulthood (n = 3,491) and BMI z score in childhood (n = 1,958). Common tag SNPs across 98 loci were also analyzed for additio ...[more]

PMID: 30887699

Similar Datasets

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Dataset Information

Assessing the Role of 98 Established Loci for BMI in American Indians.

Objective

Methods

Results

Conclusions

Publications

Assessing the Role of 98 Established Loci for BMI in American Indians.

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