Ontology highlight
ABSTRACT:
SUBMITTER: Kulkarni PS
PROVIDER: S-EPMC4096225 | biostudies-other | 2014 Jul
REPOSITORIES: biostudies-other
Kulkarni Prajakta S PS Haldar Manas K MK Nahire Rahul R RR Katti Preeya P Ambre Avinash H AH Muhonen Wallace W WW Shabb John B JB Padi Sathish K R SK Singh Raushan K RK Borowicz Pawel P PP Shrivastava D K DK Katti Kalpana S KS Reindl Katie K Guo Bin B Mallik Sanku S
Molecular pharmaceutics 20140523 7
Significant differences in biochemical parameters between normal and tumor tissues offer an opportunity to chemically design drug carriers which respond to these changes and deliver the drugs at the desired site. For example, overexpression of the matrix metalloproteinase-9 (MMP-9) enzyme in the extracellular matrix of tumor tissues can act as a trigger to chemically modulate the drug delivery from the carriers. In this study, we have synthesized an MMP-9-cleavable, collagen mimetic lipopeptide ...[more]