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Neuronal failure in Alzheimer's disease: a view through the oxidative stress looking-glass.

ABSTRACT: Considerable debate and controversy surround the cause(s) of Alzheimer's disease (AD). To date, several theories have gained notoriety, however none is universally accepted. In this review, we provide evidence for the oxidative stress-induced AD cascade that posits aged mitochondria as the critical origin of neurodegeneration in AD.

SUBMITTER: Bonda DJ 

PROVIDER: S-EPMC4097013 | biostudies-other | 2014 Apr

REPOSITORIES: biostudies-other

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