Ontology highlight
ABSTRACT:
SUBMITTER: Wawer MJ
PROVIDER: S-EPMC4121832 | biostudies-other | 2014 Jul
REPOSITORIES: biostudies-other
Proceedings of the National Academy of Sciences of the United States of America 20140714 30
High-throughput screening has become a mainstay of small-molecule probe and early drug discovery. The question of how to build and evolve efficient screening collections systematically for cell-based and biochemical screening is still unresolved. It is often assumed that chemical structure diversity leads to diverse biological performance of a library. Here, we confirm earlier results showing that this inference is not always valid and suggest instead using biological measurement diversity deriv ...[more]