Ontology highlight
ABSTRACT:
SUBMITTER: Vassalli JD
PROVIDER: S-EPMC413407 | biostudies-other | 1993 May
REPOSITORIES: biostudies-other
Vassalli J D JD Huarte J J Bosco D D Sappino A P AP Sappino N N Velardi A A Wohlwend A A Ernø H H Monard D D Belin D D
The EMBO journal 19930501 5
A search for inhibitors of urokinase-type plasminogen activator (uPA) in the male and female murine genital tracts revealed high levels of a uPA ligand in the seminal vesicle. This ligand is functionally, biochemically and immunologically indistinguishable from protease-nexin I (PN-I), a serpin ligand of thrombin and uPA previously detected only in mesenchymal cells and astrocytes. A survey of murine tissues indicates that PN-I mRNA is most abundant in seminal vesicles, where it represents 0.2-0 ...[more]