Cloning and expression of two brain-specific inwardly rectifying potassium channels.
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ABSTRACT:
SUBMITTER: Bredt DS
PROVIDER: S-EPMC41407 | biostudies-other | 1995 Jul
REPOSITORIES: biostudies-other
Publications
Cloning and expression of two brain-specific inwardly rectifying potassium channels.
Bredt D S DS Wang T L TL Cohen N A NA Guggino W B WB Snyder S H SH
Proceedings of the National Academy of Sciences of the United States of America 19950701 15
We have cloned two inwardly rectifying K+ channels that occur selectively in neurons in the brain and are designated BIRK (brain inwardly rectifying K+) channels. BIRK1 mRNA is extremely abundant and is enriched in specific brainstem nuclei, BIRK1 displays a consensus phosphate-binding loop, and expression in Xenopus oocytes has shown that its conductance is inhibited by ATP and adenosine 5'-[gamma-thio]triphosphate. BIRK2 is far less abundant and is selectively localized in telencephalic neuron ...[more]
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