Ontology highlight
ABSTRACT:
SUBMITTER: Helbling M
PROVIDER: S-EPMC4148090 | biostudies-other | 2014 Jul
REPOSITORIES: biostudies-other
Helbling Melina M Lukesch Anne A Haimovici Aladin A Karamitopoulou Eva E Berger Martin D MD Hädrich Marion M Mallaev Makhmud M Schnüriger Beat B Koelzer Viktor H VH Dawson Heather H Borner Markus M Langer Rupert R Rosenberg Robert R Nitsche Ulrich U Inderbitzin Daniel D Lugli Alessandro A Tschan Mario M Zlobec Inti I
Oncotarget 20140701 13
IL-23 is a heterodimeric cytokine involved in inflammatory diseases; its role in cancer progression is controversial. Here we analyse the expression of IL-23 subunits (p40 and p19) and IL-23R in colorectal cancer with regard to disease progression, clinical-pathological and molecular aspects. Immunohistochemistry for IL-23p19, IL-23p40, IL-23R and CD8 was performed on a multi-punch tissue microarray of 195 colorectal cancers (cohort 1), matched normal tissue, adenoma and lymph node metastases. R ...[more]