Ontology highlight
ABSTRACT:
SUBMITTER: Moss PA
PROVIDER: S-EPMC41583 | biostudies-other | 1995 Jun
REPOSITORIES: biostudies-other
Proceedings of the National Academy of Sciences of the United States of America 19950601 13
Human immunodeficiency virus (HIV)-specific cytotoxic T lymphocytes (CTLs) are thought to play a major role in the immune response to HIV infection. The HIV-specific CTL response is much stronger than previously documented in an infectious disease, yet estimates of CTL frequency derived from limiting-dilution analysis (LDA) are relatively low and comparable to other viral infections. Here we show that individual CTL clones specific for peptides from HIV gag and pol gene products are present at h ...[more]