Ontology highlight
ABSTRACT:
SUBMITTER: Rankin EB
PROVIDER: S-EPMC4169907 | biostudies-other | 2014 Sep
REPOSITORIES: biostudies-other
Rankin Erinn B EB Fuh Katherine C KC Castellini Laura L Viswanathan Kartik K Finger Elizabeth C EC Diep Anh N AN LaGory Edward L EL Kariolis Mihalis S MS Chan Andy A Lindgren David D Axelson Håkan H Miao Yu R YR Krieg Adam J AJ Giaccia Amato J AJ
Proceedings of the National Academy of Sciences of the United States of America 20140903 37
Dysregulation of the von Hippel-Lindau/hypoxia-inducible transcription factor (HIF) signaling pathway promotes clear cell renal cell carcinoma (ccRCC) progression and metastasis. The protein kinase GAS6/AXL signaling pathway has recently been implicated as an essential mediator of metastasis and receptor tyrosine kinase crosstalk in cancer. Here we establish a molecular link between HIF stabilization and induction of AXL receptor expression in metastatic ccRCC. We found that HIF-1 and HIF-2 dire ...[more]