Early assessment of high-intensity focused ultrasound treatment of benign thyroid nodules by scintigraphic means.

ABSTRACT: BACKGROUND: High-intensity focused ultrasound (HIFU) allows to inflict intracorporal thermal lesions without penetrating the skin or damaging the surrounding tissue. This analysis intends to assess the magnitude of HIFU-induced ablations within benign thyroid nodules using scintigraphic imaging with (99m)Tc. METHODS: Ten cold, hot, or indifferent nodules were treated using multiple pulses of HIFU to induce temperatures of around 85°C within the ablation zone. Pre- and posttreatment, uptake values of (99m)Tc-pertechnetate or (99m)Tc-MIBI were recorded. The pre-post reduction of nodular uptake was evaluated to assess ablation magnitude. RESULTS: Relative nodular uptake in relation to total thyroidal uptake decreased after one session of HIFU in all cases. Median (99m)Tc-MIBI uptake reduction was 35.5% (ranging from 11% to 57%; p?

SUBMITTER: Korkusuz H 

PROVIDER: S-EPMC4179864 | biostudies-other | 2014

REPOSITORIES: biostudies-other