Ontology highlight
ABSTRACT:
SUBMITTER: Gu L
PROVIDER: S-EPMC4185387 | biostudies-other | 2014
REPOSITORIES: biostudies-other
Gu Ling L Black Bryan B Ordonez Simon S Mondal Argha A Jain Ankur A Mohanty Samarendra S
Scientific reports 20141006
The precision of axonal pathfinding and the accurate formation of functional neural circuitry are crucial for an organism during development as well as during adult central and peripheral nerve regeneration. While chemical cues are believed to be primarily responsible for axonal pathfinding, we hypothesize that forces due to localized fluid flow may directly affect neuronal guidance during early organ development. Here, we report direct evidence of fluid flow influencing axonal migration, produc ...[more]