Unknown

Dataset Information

0

EPSA: A Novel Supercritical Fluid Chromatography Technique Enabling the Design of Permeable Cyclic Peptides.


ABSTRACT: Most peptides are generally insufficiently permeable to be used as oral drugs. Designing peptides with improved permeability without reliable permeability monitoring is a challenge. We have developed a supercritical fluid chromatography technique for peptides, termed EPSA, which is shown here to enable improved permeability design. Through assessing the exposed polarity of a peptide, this technique can be used as a permeability surrogate.

SUBMITTER: Goetz GH 

PROVIDER: S-EPMC4190640 | biostudies-other | 2014 Oct

REPOSITORIES: biostudies-other

Similar Datasets

| S-EPMC7577319 | biostudies-literature
| S-EPMC4522036 | biostudies-literature
| S-EPMC5662104 | biostudies-literature
| S-EPMC6127797 | biostudies-literature
| S-EPMC6193530 | biostudies-literature
| S-EPMC6972688 | biostudies-literature
| S-EPMC7118041 | biostudies-literature
| S-EPMC5549281 | biostudies-literature
| S-EPMC6027907 | biostudies-other
| S-EPMC6273052 | biostudies-literature