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Physical mapping, cloning, and identification of genes within a 500-kb region containing BRCA1.

ABSTRACT: BRCA1 is a breast/ovarian cancer susceptibility gene on human chromosome 17q21. We describe a complete and detailed physical map of a 500-kb region of genomic DNA containing the BRCA1 gene and the partial cloning in phage P1 artificial chromosomes. Approximately 70 exons were isolated from this region, 11 of which were components of the BRCA1 gene. Analysis of the other exons revealed a rho-related G protein and the interferon-induced leucine-zipper protein IFP-35.

SUBMITTER: Brown MA

PROVIDER: S-EPMC41944 | biostudies-other | 1995 May

REPOSITORIES: biostudies-other

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Physical mapping, cloning, and identification of genes within a 500-kb region containing BRCA1.

Brown M A MA Jones K A KA Nicolai H H Bonjardim M M Black D D McFarlane R R de Jong P P Quirk J P JP Lehrach H H Solomon E E

Proceedings of the National Academy of Sciences of the United States of America 19950501 10

BRCA1 is a breast/ovarian cancer susceptibility gene on human chromosome 17q21. We describe a complete and detailed physical map of a 500-kb region of genomic DNA containing the BRCA1 gene and the partial cloning in phage P1 artificial chromosomes. Approximately 70 exons were isolated from this region, 11 of which were components of the BRCA1 gene. Analysis of the other exons revealed a rho-related G protein and the interferon-induced leucine-zipper protein IFP-35. ...[more]

PMID: 7753812

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