Ontology highlight
ABSTRACT:
SUBMITTER: Perez Bay AE
PROVIDER: S-EPMC4197088 | biostudies-other | 2014 Oct
REPOSITORIES: biostudies-other
Perez Bay Andres E AE Schreiner Ryan R Benedicto Ignacio I Rodriguez-Boulan Enrique J EJ
Journal of cell science 20140901 Pt 20
Some native epithelia, for example, retinal pigment epithelium (RPE) and kidney proximal tubule (KPT), constitutively lack the basolateral sorting adaptor AP-1B; this results in many basolateral plasma membrane proteins being repositioned to the apical domain, where they perform essential functions for their host organs. We recently reported the underlying apical polarity reversal mechanism: in the absence of AP-1B-mediated basolateral sorting, basolateral proteins are shuttled to the apical pla ...[more]