Ontology highlight
ABSTRACT:
SUBMITTER: Wang P
PROVIDER: S-EPMC4206533 | biostudies-other | 2014 Sep
REPOSITORIES: biostudies-other
Wang Pei P Xu Tian-Ying TY Wei Kai K Guan Yun-Feng YF Wang Xia X Xu Hui H Su Ding-Feng DF Pei Gang G Miao Chao-Yu CY
Autophagy 20140625 9
Autophagy, a highly conserved process conferring cytoprotection against stress, contributes to the progression of cerebral ischemia. β-arrestins are multifunctional proteins that mediate receptor desensitization and serve as important signaling scaffolds involved in numerous physiopathological processes. Here, we show that both ARRB1 (arrestin, β 1) and ARRB2 (arrestin, β 2) were upregulated by cerebral ischemic stress. Knockout of Arrb1, but not Arrb2, aggravated the mortality, brain infarction ...[more]