Indazole-type alkaloids from Nigella sativa seeds exhibit antihyperglycemic effects via AMPK activation in vitro.
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ABSTRACT:
SUBMITTER: Yuan T
PROVIDER: S-EPMC4208670 | biostudies-other | 2014 Oct
REPOSITORIES: biostudies-other
Publications
Indazole-type alkaloids from Nigella sativa seeds exhibit antihyperglycemic effects via AMPK activation in vitro.
Yuan Tao T Nahar Pragati P Sharma Meenakshi M Liu Ke K Slitt Angela A Aisa H A HA Seeram Navindra P NP
Journal of natural products 20141009 10
Six rare naturally occurring indazole-type alkaloids including two new compounds, 17-O-(β-d-glucopyranosyl)-4-O-methylnigellidine (1) and nigelanoid (2), and four known compounds (3-6) were isolated from a defatted extract of Nigella sativa (black cumin) seeds. 17-O-(β-d-Glucopyranosyl)-4-O-methylnigellidine (1) increased glucose consumption by liver hepatocytes (HepG2 cells) through activation of AMP-activated protein kinase (AMPK). Also, this is the first report of compounds 4 and 6 from a nat ...[more]
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