Ontology highlight
ABSTRACT:
SUBMITTER: Tahara N
PROVIDER: S-EPMC4212241 | biostudies-other | 2014 Oct
REPOSITORIES: biostudies-other
Tahara Nobuhiro N Zandbergen H Reinier HR de Haas Hans J HJ Petrov Artiom A Pandurangi Raghu R Yamaki Takayoshi T Zhou Jun J Imaizumi Tsutomu T Slart Riemer H J A RH Dyszlewski Mary M Scarabelli Tiziano T Kini Annapoorna A Reutelingsperger Chris C Narula Navneet N Fuster Valentin V Narula Jagat J
Scientific reports 20141029
Acute insult to the myocardium is associated with substantial loss of cardiomyocytes during the process of myocardial infarction. In this setting, apoptosis (programmed cell death) and necrosis may operate on a continuum. Because the latter is characterized by the loss of sarcolemmal integrity, we propose that an appropriately labeled tracer directed at a ubiquitously present intracellular moiety would allow non-invasive definition of cardiomyocyte necrosis. A trivalent arsenic peptide, GSAO (4- ...[more]