Ontology highlight
ABSTRACT:
SUBMITTER: Depelsenaire ACI
PROVIDER: S-EPMC4216316 | biostudies-other | 2014 Sep
REPOSITORIES: biostudies-other
Depelsenaire Alexandra C I ACI Meliga Stefano C SC McNeilly Celia L CL Pearson Frances E FE Coffey Jacob W JW Haigh Oscar L OL Flaim Christopher J CJ Frazer Ian H IH Kendall Mark A F MAF
The Journal of investigative dermatology 20140408 9
Vaccines delivered to the skin by microneedles-with and without adjuvants-have increased immunogenicity with lower doses than standard vaccine delivery techniques such as intramuscular or intradermal injection. However, the mechanisms underlying this skin-mediated "adjuvant" effect are not clear. Here, we show that the dynamic application of a microprojection array (the Nanopatch) to skin generates localized transient stresses invoking cell death around each projection. Nanopatch application cau ...[more]