Remission of disseminated cancer after systemic oncolytic virotherapy.
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ABSTRACT:
SUBMITTER: Russell SJ
PROVIDER: S-EPMC4225126 | biostudies-other | 2014 Jul
REPOSITORIES: biostudies-other
Publications
Remission of disseminated cancer after systemic oncolytic virotherapy.
Russell Stephen J SJ Federspiel Mark J MJ Peng Kah-Whye KW Tong Caili C Dingli David D Morice William G WG Lowe Val V O'Connor Michael K MK Kyle Robert A RA Leung Nelson N Buadi Francis K FK Rajkumar S Vincent SV Gertz Morie A MA Lacy Martha Q MQ Dispenzieri Angela A
Mayo Clinic proceedings 20140514 7
MV-NIS is an engineered measles virus that is selectively destructive to myeloma plasma cells and can be monitored by noninvasive radioiodine imaging of NIS gene expression. Two measles-seronegative patients with relapsing drug-refractory myeloma and multiple glucose-avid plasmacytomas were treated by intravenous infusion of 10(11) TCID50 (50% tissue culture infectious dose) infectious units of MV-NIS. Both patients responded to therapy with M protein reduction and resolution of bone marrow plas ...[more]
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